Researchers from Amgen, a pharmaceutical company, attempted to replcate 53 haematological and oncological preclinical trials that informed major articles on related drugs. The researchers were able to replicate only 6 of the 53 described preclinical trials.
Some of the authors of the preclinical trials, which the researchers were unable to replicate, admitted to suppressing data that did not support their hypotheses.
Here are some other studies that support Prescrire's conclusions:
Industry-Sponsored Clinical Research: A Double-Edged Sword
Implications of Pharmaceutical Industry Funding on Clinical Research
Uneasy Alliance — Clinical Investigators and the Pharmaceutical Industry
Financial Conflict-of-Interest Policies in Clinical Research: Issues for Clinical Investigators
Randomized clinical trials: What gets published, and when?
Prescrire, along with www.alltrials.net are calling for transparent, available, and publicly accessible raw data so that independent analyses and scrutiny of trials results - for medications that are prescribed to all of us - can verify that reported conclusions have been accurately drawn from complete data sets. Sign the AllTrials petition now.
Health Research: Fraud is Too Widespread (to access the .pdf, click "Pdf, free" at bottom of article)